Quadro K4000 vs Quadro K4100M specs and performance
According to the hardwareDB Benchmark, the Quadro K4000 GPU is faster than the Quadro K4100M in gaming.
Furthermore, the spec sheet for both these GPUs show that the Quadro K4100M has slightly more memory with 4 GiB of memory compared to 3 GiB. Memory size doesn't directly affect performance, but too little memory will certainly degrade gaming performance.
In addition, the Quadro K4000 has a slightly lower TDP at 80 W when compared to the Quadro K4100M at 100 W. This is not a measure of performance, but rather the amount of heat generated by the chip when running at its highest speed.
In conclusion, all specs and GPU benchmarks considered, will recommend the Quadro K4000 over the Quadro K4100M.
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